Chemical intermediate is any chemical substance produced during the conversion of some reactant to a product. Most synthetic processes involve transformation of some readily available and often inexpensive substance to some desired product through a succession of steps. All the substances generated by one step and used for the succeeding step are considered intermediates. A reaction intermediate or an intermediate is a molecular entity that is formed from the reactants (or preceding intermediates) and reacts further to give the directly observed products of a chemical reaction. Pharmaceutical Formulation Intermediates (or PFI) is a commercial terminology used for Direct Compressible (DC). It comprises a mixture of active substances and excipients, usually in powder form.